{"id":7251,"date":"2021-06-15T01:53:30","date_gmt":"2021-06-14T23:53:30","guid":{"rendered":"https:\/\/hepmp.med.bg.ac.rs\/?p=7251"},"modified":"2021-09-13T01:59:03","modified_gmt":"2021-09-12T23:59:03","slug":"farmakokinetika-i-farmakodinamija-anestetika-tci-i-deo","status":"publish","type":"post","link":"https:\/\/hepmp.med.bg.ac.rs\/?p=7251","title":{"rendered":"Farmakokinetika i farmakodinamija anestetika: TCI I deo"},"content":{"rendered":"<p>Predavanje Farmakokinetika i farmakodinamija anestetika: TCI I deo odr\u017eano je 15 juna 2021. Predavanje je odr\u017eao profesor Predrag Stevanovi\u0107.<\/p>\n<p>Predavanje je dostupno na linku\u00a0<a href=\"https:\/\/youtu.be\/jKs4JTKTPGs\">https:\/\/youtu.be\/jKs4JTKTPGs\u00a0<\/a><\/p>\n<h3>Materijal<\/h3>\n<p>Agenda \u2013 <a href=\"https:\/\/hepmp.med.bg.ac.rs\/wp-content\/uploads\/2021\/09\/Agenda-upcoming-event-farmakokinetika-i-farmakodinamija.docx\">preuzeti<\/a><br \/>\nReport \u2013 <a href=\"https:\/\/hepmp.med.bg.ac.rs\/wp-content\/uploads\/2021\/09\/Event-report-farmakokinetika-i-farmakodinamija-2-online-19.6.21.docx\">preuzeti<\/a><br \/>\nSpisak prisutnih &#8211; <a href=\"https:\/\/hepmp.med.bg.ac.rs\/wp-content\/uploads\/2021\/09\/Attendance-list-farmakokinetika-i-farmakodinamija-.docx\">preuzeti<\/a><\/p>\n<h3>O predavanju<\/h3>\n<p>Farmakokinetika kvantitativno karakteri\u0161e procese kojima lek u organizmu podle\u017ee. Farmakodinamija podrazumeva interakciju leka sa receptorom i\/ili enzimom koja se mo\u017ee predstaviti sigmoidnom krivom i matemati\u010dkom formulom. U cilju kvantitativnog prou\u010davanja kineti\u010dkih procesa kojima lek u organizmu podle\u017ee uvedena je prostorna odnosno model zavisna analiza.<\/p>\n<p>Razvojem anesteti\u010dkih lekova kratkog dejstva, pobolj\u0161anih tehnika ispitivanja lekova i dostupnost pouzdanih infuzionih sistema otvorili su polje klini\u010dke farmakokinetike i farmakodinamije. Troeksponencijalni pad koncentracije leka komplikuje definiciju terapijskih re\u017eima doziranja i spre\u010dava jednostavno predvi\u0111anje oporavka od efekata leka. Kontekst-osetljivo poluvreme, vreme potrebno da se koncentracija leka u krvi smanji na polovinu vrednosti, pru\u017ea koristan uporedni prediktor pada koncentracije leka nakon infuzije. Vreme izjedna\u010davanja na mestu efekta doprinosi odlaganju dejstva leka i poja\u010dava neravnote\u017eu izme\u0111u koncentracija leka u krvi i postignutog efekta nakon postepenog doziranja. Obrazlo\u017eenje za infuziju leka je smanjenje promenljivih koncentracija leka i efekata lekova. Varijabilnost sli\u010dna onoj koja se primec\u0301uje pri upotrebi inhalacionih sredstava mora se postic\u0301i izborom odgovarajuc\u0301eg farmakokineti\u010dkog modela. Upotreba ciljanog kontrolisanog infuzionog ure\u0111aja, koji isporu\u010duje proporcionalne promene zasnovane na farmakokineti\u010dkim principima, omoguc\u0301ava titraciju koncentracije u odnosu na klini\u010dki efekat kod pojedina\u010dnih pacijenata.<\/p>\n<p>Na predavanju \u0107e biti prezentovani matemati\u010dki modeli farmakodinamije, farmakokinetski parametri koji kvantitativno tuma\u010de dispoziciju anestetika kao i kako farmakokinetika poma\u017ee razvoju racionalnih doznih uputstava za intravenske anestetike.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Predavanje Farmakokinetika i farmakodinamija anestetika: TCI I deo odr\u017eano je 15 juna 2021. Predavanje je odr\u017eao profesor Predrag Stevanovi\u0107. Predavanje je dostupno na linku\u00a0https:\/\/youtu.be\/jKs4JTKTPGs\u00a0 Materijal Agenda \u2013 preuzeti Report \u2013 preuzeti Spisak prisutnih &#8211; preuzeti O predavanju Farmakokinetika kvantitativno karakteri\u0161e procese kojima lek u organizmu podle\u017ee. Farmakodinamija podrazumeva interakciju leka sa receptorom i\/ili enzimom koja <a href=\"https:\/\/hepmp.med.bg.ac.rs\/?p=7251\" rel=\"nofollow\"><span class=\"sr-only\">Read more about Farmakokinetika i farmakodinamija anestetika: TCI I deo<\/span>[&hellip;]<\/a><\/p>\n","protected":false},"author":1,"featured_media":44,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,6],"tags":[],"class_list":["post-7251","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-events","category-event-report"],"_links":{"self":[{"href":"https:\/\/hepmp.med.bg.ac.rs\/index.php?rest_route=\/wp\/v2\/posts\/7251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hepmp.med.bg.ac.rs\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hepmp.med.bg.ac.rs\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hepmp.med.bg.ac.rs\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hepmp.med.bg.ac.rs\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7251"}],"version-history":[{"count":1,"href":"https:\/\/hepmp.med.bg.ac.rs\/index.php?rest_route=\/wp\/v2\/posts\/7251\/revisions"}],"predecessor-version":[{"id":7252,"href":"https:\/\/hepmp.med.bg.ac.rs\/index.php?rest_route=\/wp\/v2\/posts\/7251\/revisions\/7252"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hepmp.med.bg.ac.rs\/index.php?rest_route=\/wp\/v2\/media\/44"}],"wp:attachment":[{"href":"https:\/\/hepmp.med.bg.ac.rs\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7251"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hepmp.med.bg.ac.rs\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7251"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hepmp.med.bg.ac.rs\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}